| clsormagazine |
It took another
half a century before Isaac Newton, an Englishman well beyond the Church's
reach, was able to take their controversial findings and establish the
modern physical sciences, the bedrock of our society and the way we look
at the world.
Right now,
today, the world is teetering on the brink of a new Enlightenment. Only
this time, it's not about where we are. It's about what we are, how we're
put together and the origins of life itself.
If you've
paid attention to any news over the past five years, you've heard of stem
cells. You know they've got something to do with clones (oooh! science
fiction!), and you've probably heard something about angry debates in
Congress, and, if you're anything close to the average American, that's
about it. The fact that you're not up to date on the latest scientific
minntiae shouldn't scare you. The fact that your politicians aren't either
should.
Stem cell
research "represents the dawn of a new age in medicine," says
Michael West, president of Advanced Cell Technology (ACT) of Worcester,
Massachusetts. He should know. After years of backbreaking work, last
Halloween his company produced the first human clones, artificially spawned
embryos that lasted all of five days and measured about the size of the
head of a pin. West's research team wasn't hoping to create Xerox copies
of themselves, or even an army of genetically advanced super-soldiers.
|
"Scientifically,
biologically, the entities we are creating are not individuals,"
he explains. "They're only cellular life. They're not human
life." What ACT and hundreds of similar laboratories are after
are stem cells. These functionally immortal cells can develop into
any type of cell in the body. They can replace anything in you that's
alive. Heart attack? Have it rebuilt. Alzheimer's? Here's some new
brain tissue. Diabetes? Pancreas replaced while you wait. What these
researchers are after is nothing less than the Holy Grail of medical
research.
Unfortunately, a lot of very important people don't see it that
way.
For
the scientists, here's the crux of the debate: cloning technology
will someday cure millions of sick and dying people by creating
unrejectable transplant tissues out of genetically identical stem
cells. It will be a revolution bigger than the discovery of antibiotics.
For
the religious right, however, the issue becomes tainted twice-once
with the Frankensteinian notion of white-coated madmen creating
human Xeroxes, and again
|
 |
(much more seriously)
with the thought of where the raw material for these super-duper tissue
transplants actually comes from. Human embryos. You know, babies. Being
harvested for their organs.
It's not
a pretty thought. Luckily, it's not an accurate one either.
Biology lesson
So what
are stem cells?
They're the
raw material your body is made from, and they come in three basic flavors:
totipotent, pluripotent, and multipotent.
Totipotent
stem cells can create any organ in the body, including the placenta that
feeds a growing embryo in the womb. Think of a fertilized egg-a single
cell that can eventually become a human being.
Pluripotent
stem cells are those capable of becoming any kind of tissue except a placenta.
They're found once a fertilized egg has multiplied enough to form a nearly
microscopic, hollow ball called a blastocyst. These are the "blank
slate" cells, the ultra-useful super cells that all the fuss is about.
They tend not to last in an embryo more than a few weeks before becoming
specialized cells-eyes, kidneys, genitals, toenails, whatever.
Multipotent
stem cells give rise to specific kinds of specialized cells; for example,
the multipotent stem cells in bone marrow produce white blood cells, platelets
and red blood cells. They exist in adults, but have proved very hard to
harvest and even harder to work with. It's not easy turning blood into
pancreatic tissue, even on the cellular level.
So, thus
far, researchers have been feeling their way around the new technology
using pluripotent cells, which offer the greatest results with the least
amount of effort. The problem is, the best source for these is human embryos,
and if you're a legitimate research scientist, there's only two places
you can get those. The first is abortion clinics-and we all know the political
land mines surrounding these. The second, ironically, is fertility clinics.
In an August
9 television address, President Bush spoke out against embryonic research,
yet praised in vitro fertilization (IVF) as a "process... which helps
so many couples conceive children."
His advisers
must not have mentioned to him that the "family friendly" process
generates thousands of unused human embryos. They're routinely thawed
out and discarded. Bear in mind, we're not talking black rubber bags filled
with wriggling fetuses here. We're talking about clusters of a dozen cells
or so which have shown an ability to reproduce themselves. Most of them
wouldn't develop into fetuses even if given a chance. But for stem cell
researchers, this is a gold mine-one which the government is busy putting
a barbed wire fence around.
For the
right-to-life lobby, the idea that human life begins at conception-even
before cells begin to divide-is an absolute certainty, based on the revealed
truth of God. Scientists enjoy no such certainty. And in our system, lack
of certainty can be a big political problem. When conservative Congressional
committees ask researchers if they're destroying a potential human life,
the answer "kinda, but not really" just doesn't cut it.
The controversy isn't necessarily helped by certain elements in the progressive
camp, either. Take, for example, the Raelians, a UFO cult following the
teachings of an enlightened Canadian sportswriter who now goes by his
space-name, Ra-El. They're behind organizations like Clonaid (a very real
scientific entity) because of their belief that only once humanity achieves
immortality through cloning will we be united with our Blessed Space Brothers.
Clonaid's director, chemist Brigitte Boisselier, was in Washington, D.C.
this August, one of hundreds of scientists gathered at the National Academy
of Sciences to discuss the scientific ethics of cloning.
"We
need to proceed with human cloning," she declared. "I believe
it's a fundamental right to reproduce the way you want."
You may remember the conference. Unlike most scientific summits, this
one featured angry protestors and hourly updates on CNN. The meeting ended
with a panel of scientists assigned to hack their way through the ethical
jungle dividing science and the law. As this article goes to press, the
panel has yet to issue its recommendations to the legislature.
There's little time to lose. Last July, before the meeting took place,
the House of Representatives voted to make all embryonic stem cell research
a federal crime. The bill was drafted by Florida's own Rep. Dave Weldon
(R). Floridian Peter Deutsch (D) and Pennsylvanian Jim Greenwood (R) sponsored
an amendment making Rael-style reproductive cloning illegal but allowing
doctors to continue therapeutic research. It was voted down. When the
bill reached the Senate, it decided to put off its vote for a few months.
This was partially due to anthrax attacks on pro-cloning legislators Tom
Daschle (D) and Arlen Specter (R). (Not that this humble typist wishes
to draw any conclusions.)
After the House vote, White House spokesman Ari Fleischer crowed: "The
president is pleased that it passed. It has the proper measure of ethics,
science and respect for a culture that places value on life."
It's not over 'til the fat lady sings
A similar
bill in Britain last summer banned reproductive cloning-which even advocates
admit is a hazardous, imperfect process-while allowing vitally important
stem cell research to continue. At least one American researcher, Roger
Pedersen of the University of California at San Francisco, is emigrating
to the United Kingdom to continue his work unrestricted. He could be the
first of many.
On the heels of the House vote, George W. Bush cut funding for embryonic
stem cell research. Researchers who depend on federal funding are now
limited to working with 60 already-existing cell lines, "where a
life-and-death decision has already been made." In other words, the
embryos that produced the lines have already been destroyed. If it turns
out that there's some problem with those 60 cell families, tough luck.
Even by allowing this extremely limited funding, the president risked
alienating himself from the core of his own party and violated one of
his own campaign promises. He also put the task of pioneering this brave
new science on the shoulders of privately funded biotech entrepreneurs,
rather than publicly responsible university labs. Already, researchers
are petitioning the National Institutes of Health to make privately owned
cell lines available to the public research community-but as far as biotech
business is concerned, information is never free. It's intellectual property.
It comes with a price. That is, if Congress doesn't succeed in outlawing
it first.
As the government lumbers ponderously towards a total ban on embryonic
stem cell research, the medical revolution is blazing forward. And, as
is often the case, the latest findings are leaving the dogma-bound opposition
in the dust. If the scientists can only continue unhindered long enough,
cells from human embryos will be rendered obsolete. Instead, the medical
revolutionaries will be living off the fat of the land-literally.
"Adult tissues don't appear to be as restricted as they once were,"
explains University of Florida neurologist Dennis Steindler. "Once
we figure out their molecular genetics, we should be able to coax them
into becoming almost anything we want them to be."
Steindler is working with stem cells harvested from the brains of adult
cadavers. It's pretty safe business-the religious right long ago abandoned
their opposition to plundering the dead for the sake of the living. But
one of Steindler's colleagues is doing him one better. Adam Katz of the
University of Pittsburgh School of Medicine has been looking for stem
cells in the less-than-appetizing "slurry" sucked out during
liposuction.
"We can take gallons and gallons," he beams. "Most people
are more than willing to part with it. Usually we just throw it away."
Katz decided to see what would happen when he mixed the slurry up with
growth factors, chemicals that stimulate stem cells into reproducing.
When his team tested the mixture, they found some of the cells floating
in the slurry weren't fat anymore. Instead, they had turned into bone,
cartilage and muscle cells-just as embryonic stem cells do. Now, it's
just up to researchers to figure out how to isolate those stem cells...
how to transform America's beer guts and cellulite into the Holy Grail
of medicine.
Galileo's
observations took a lifetime to flower into Newton's descriptions of the
universe, but the stem cell revolution is taking place right now, on a
scale of weeks, not years. Doctors recently announced a stunning success
using stem cells to regrow severed optic nerves. Think of it: new eyes
for the blind. Another team reported stem cell injections seem to help
repair brain damage in stroke victims. Leukemia victims are already conquering
their illness with stem cell therapy. This is already happening, without
the imprimatur of the federal government.
By the time the Senate gets around to their vote, there's no telling what
breakthroughs will have taken place-how many lives will have been saved-without
their having lifted a finger to stop it.
|